The department of medicine is one of the premier departments of M.O.S.C medical college. Patients get referred to this department mainly from the three districts of Ernakulam, Kottayam and the hilly district of Idukki. Besides, this department also caters to the local population. Being a major referral hospital east of the metropolitan area of Ernakulum this department serves as a tertiary care center for many hospitals from the neighboring towns and villages. In addition to patient care the department is also involved in teaching M.B.B.S students. There are four medical units headed by experienced faculty. In 2011 the department was upgraded as a post-graduate training center by the Indian Medical Council.